FIGURE

FIGURE 6

ID

ZDB-FIG-240503-17

Publication

Zeng et al., 2024 - Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway

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FIGURE 6

Loss of Cobll1a resulted in Abnormal Lipid Metabolism in Zebrafish. (A) Clustering heat maps of lipid anabolism-related genes in DEGs. WT and cobll1a mutated zebrafish embryo samples form two distinct groups. (B) RT-qPCR used to assess transcriptional expression level of lipid anabolism-related genes in cobll1a^−/− embryos at 52 hpf, compared with WT. (C) RT-qPCR analysis of transcriptional expression level of lipid catabolism-related genes in cobll1a^−/− embryos at 52 hpf, compared to the control. (D) At 4 dpf, fasn is expressed in adipocytes and the expression of fasn is up-regulated in cobll1a^−/− embryos. (E) At 5 dpf, Oil Red O staining was used to assess the lipid distribution and content of WT and cobll1a^−/− embryos.

Expression Data

Genes:	dgat1a elovl2 elovl6 fasn lipca lpla scd srebf1 srebf2
Fish:	TU cobll1a^hn17/hn17 (TU)
Anatomical Terms:	adipose tissue whole organism
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cobll1a^hn17/hn17 (TU)
Observed In:	adipose tissue lipid catabolic process lipid metabolic process whole organism
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

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