Gene
lpla
- ID
- ZDB-GENE-990415-139
- Name
- lipoprotein lipase a
- Symbol
- lpla Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have apolipoprotein binding activity and lipase activity. Involved in definitive hemopoiesis and response to (R)-carnitine. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; immature eye; midbrain; and pleuroperitoneal region. Orthologous to human LPL (lipoprotein lipase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77678 (16 images)
- IMAGE:7152644 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Liu et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial combined hyperlipidemia | Alliance | Combined hyperlipidemia, familial | 144250 |
| familial lipoprotein lipase deficiency | Alliance | Lipoprotein lipase deficiency | 238600 |
| familial lipoprotein lipase deficiency | Alliance | [High density lipoprotein cholesterol level QTL 11] | 238600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001024 | PLAT/LH2 domain |
| Domain | IPR013818 | Lipase |
| Domain | IPR033906 | Lipase, N-terminal |
| Family | IPR000734 | Triacylglycerol lipase family |
| Family | IPR002330 | Lipoprotein lipase |
| Family | IPR016272 | Lipase, LIPH-type |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
| Homologous_superfamily | IPR036392 | PLAT/LH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha/Beta hydrolase fold | Lipase | Lipase, LIPH-type | Lipase, N-terminal | Lipoprotein lipase | PLAT/LH2 domain | PLAT/LH2 domain superfamily | Triacylglycerol lipase family |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6P2U2
|
511 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available