Gene

lpl

ID
ZDB-GENE-990415-139
Name
lipoprotein lipase
Symbol
lpl Nomenclature History
Previous Names
  • fb62e04
  • fc49b03
  • wu:fb62e04 (1)
  • wu:fc49b03 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Involved in definitive hemopoiesis and response to (R)-carnitine. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 20 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Liu et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lpl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial combined hyperlipidemia Alliance Combined hyperlipidemia, familial 144250
familial lipoprotein lipase deficiency Alliance Lipoprotein lipase deficiency 238600
familial lipoprotein lipase deficiency Alliance [High density lipoprotein cholesterol level QTL 11] 238600
Associated With lpl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001024 PLAT/LH2 domain
Domain IPR013818 Lipase/vitellogenin
Domain IPR033906 Lipase, N-terminal
Family IPR000734 Triacylglycerol lipase family
Family IPR002330 Lipoprotein lipase
Family IPR016272 Lipase, LIPH-type
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Lipase, LIPH-type Lipase, N-terminal Lipase/vitellogenin Lipoprotein lipase PLAT/LH2 domain PLAT/LH2 domain superfamily Triacylglycerol lipase family
UniProtKB:F1QHK8 511
UniProtKB:Q788V1 52
UniProtKB:Q92173 330
UniProtKB:Q6P2U2 511
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations