Gene
lipca
- ID
- ZDB-GENE-040426-1361
- Name
- lipase, hepatic a
- Symbol
- lipca Nomenclature History
- Previous Names
-
- lipc
- zgc:64081
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64081 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016069Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa189 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa12401 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20975 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
| Hepatic lipase deficiency | 614025 | ||
| [High density lipoprotein cholesterol level QTL 12] | 612797 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Hepatic lipase | Lipase | Lipase, LIPH-type | Lipase, N-terminal | PLAT/LH2 domain | PLAT/LH2 domain superfamily | Triacylglycerol lipase family |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T359 | InterPro | 514 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-261O24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64081 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191138 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201022 (1) | 1733 nt | ||
| Genomic | GenBank:BX957301 (2) | 64006 nt | ||
| Polypeptide | UniProtKB:Q7T359 (1) | 514 aa |
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Feng, J., Chen, X., Wang, S., Zhang, J., Wang, Q., Guo, S., Shen, Q. (2023) Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish. Food & function. 14(8):3641-3658
- Zhong, S., Chen, L., Li, X., Wang, X., Ji, G., Sun, C., Liu, Z. (2023) Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation. Communications biology. 6:824824
- Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., He, J. (2021) Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics. 17:e1009980
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., Li, M. (2020) Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network. International Journal of Molecular Sciences. 21(3):
- Marchi, D., Santhakumar, K., Markham, E., Li, N., Storbeck, K.H., Krone, N., Cunliffe, V.T., van Eeden, F.J.M. (2020) Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae. PLoS Genetics. 16:e1008757
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