Gene

lipca

ID

ZDB-GENE-040426-1361

Name

lipase, hepatic a

Symbol

lipca Nomenclature History

Previous Names

lipc
zgc:64081

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Involved in response to hormone. Predicted to localize to extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64081 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lipca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, noninsulin-dependent}	125853
		Hepatic lipase deficiency	614025
		[High density lipoprotein cholesterol level QTL 12]	612797

Associated With lipca Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013818	Lipase
Domain	IPR033906	Lipase, N-terminal
Family	IPR000734	Triacylglycerol lipase family
Family	IPR002333	Hepatic lipase
Family	IPR016272	Lipase, LIPH-type
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily