FIGURE

Fig. 2

ID

ZDB-FIG-240424-44

Publication

Xu et al., 2024 - Vibrio cholerae arrests intestinal epithelial proliferation through T6SS-dependent activation of the bone morphogenetic protein pathway

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Fig. 2

Progenitor-specific activation of BMP signaling requires Vc-commensal interactions (A and B) Posterior midguts of (A) germ-free (GF) or (B) conventionally reared (CR) esgts/+ adult flies uninfected or infected with C6706 for 24 h. Hoechst labels DNA (blue); Arm/Pros label cell borders and enteroendocrine cells, respectively (yellow); GFP labels progenitors (green); and pMAD labels cells with BMP activation (magenta). Scale bars: 15 μm. (C) Percentage of GFP+ progenitors that are pMAD+ in GF and CR esgts/+ flies. (D) Proportion of GFP+ progenitors in all intestinal epithelial cells in GF and CR esgts/+ flies. Each dot represents a measurement from a single fly gut. p values are calculated using unpaired Student’s t tests.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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