FIGURE

Fig. 3

ID

ZDB-FIG-240424-45

Publication

Xu et al., 2024 - Vibrio cholerae arrests intestinal epithelial proliferation through T6SS-dependent activation of the bone morphogenetic protein pathway

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Fig. 3

Vc-responsive activation of BMP requires IMD activity (A and B) Posterior midguts of (A) wild-type (WT) and (B) imd null mutant (imd−/−) adult flies uninfected or infected with C6706 for 24 h. Hoechst labels DNA (blue); Arm/Pros label cell borders and enteroendocrine cells, respectively (yellow); and pMAD labels cells with BMP activation (magenta). Arrows: pMAD+ progenitor cells. Scale bars: 15 μm. (C) Percentage of progenitors that are pMAD+ in WT and imd−/− flies. (D) Percentage of pMAD+ progenitors in esgts>relRNAi and Myo1Ats>relRNAi flies. Each dot represents a measurement from a single fly gut. p values are calculated using unpaired Student’s t tests.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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