FIGURE

Fig. 5

ID

ZDB-FIG-240410-5

Publication

Oliveira Silva et al., 2024 - Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles

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Fig. 5

Acute toxicity in the zebrafish embryo and larval behavior test. (A) Timeline of the experiments. Created with BioRender.com. (B) Mortality (%) and (C) hatching (%) of zebrafish embryos from the control group and after exposure to 10 μg/mL DNZ, EVs-DNZ, and NPs-PLA-PEG-DNZ containing an equivalent of 10 μg/mL of DNZ during 72 h. (D) Representative morphology of zebrafish embryos exposed to the nanoformulations. (E) The locomotor activity of zebrafish larvae on the sixth day after treatment with the free drug DNZ, or both nanoformulations. Tests were performed from 3 replicate trials using 10 embryos at each dose. Values are expressed as mean ± SEM, *p < 0.05 vs control. One-way ANOVA followed by Tukey as a post hoc comparison

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Nanomedicine