FIGURE

Fig. 1

ID

ZDB-FIG-240410-1

Publication

Oliveira Silva et al., 2024 - Donepezil-Loaded Nanocarriers for the Treatment of Alzheimer's Disease: Superior Efficacy of Extracellular Vesicles Over Polymeric Nanoparticles

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Fig. 1

Characterization of EVs-DNZ and synthetic NPs-PLA-PEG-DNZ. (A and D) A representative TEM image of EVs-DNZ and NPs-PLA-PEG-DNZ. Scale bar, 100 nm. (B, E, and F) Size distribution of EVs-DNZ and NPs-PLA-PEG-DNZ measured by NTA. (C) Western blot analysis of EVs isolated from human plasma and cell lysates to confirm the expression of the EVs marker proteins CD63, TSG101, and Calnexin (as negative control). (G) Zeta potential, (H) PDI, and (I) encapsulation efficiency and drug loading of EVs-DNZ and NPs-PLA-PEG-DNZ. Data are shown as mean ± SEM. n = 3 per group, unpaired t-test. (J) In vitro drug release study of free DNZ, EVs-DNZ, and NPs-PLA-PEG-DNZ. Data are presented as mean ± SEM (n = 3 per group) with *p < 0.05, **p < 0.01, ***p< 0.001, and ****p < 0.0001 vs free DNZ; and #p < 0.05, ##p < 0.01 vs NPs-PLA-PEG-DNZ. (K and L) Effect of drug encapsulation on size, zeta potential, and PDI. Data are presented as mean ± SEM (n=3).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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