ZFIN Image: Oliveira Silva et al., 2024, Fig. 5

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Figure Caption

Fig. 5 Acute toxicity in the zebrafish embryo and larval behavior test. (A) Timeline of the experiments. Created with BioRender.com. (B) Mortality (%) and (C) hatching (%) of zebrafish embryos from the control group and after exposure to 10 μg/mL DNZ, EVs-DNZ, and NPs-PLA-PEG-DNZ containing an equivalent of 10 μg/mL of DNZ during 72 h. (D) Representative morphology of zebrafish embryos exposed to the nanoformulations. (E) The locomotor activity of zebrafish larvae on the sixth day after treatment with the free drug DNZ, or both nanoformulations. Tests were performed from 3 replicate trials using 10 embryos at each dose. Values are expressed as mean ± SEM, *p < 0.05 vs control. One-way ANOVA followed by Tukey as a post hoc comparison

Acknowledgments

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