FIGURE

Figure 6

ID

ZDB-FIG-240229-195

Publication

Zhang et al., 2024 - Nomo1 deficiency causes autism-like behavior in zebrafish

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Figure 6

nomo1 mutant induce brain inflammatory in the brain, MC treatment rescued the small circling behavior.

(A) GO enrichment analysis of DEGs and (B) KEGG pathway analysis of DEGs. Advanced bubble chart showing the enrichment of DEGs in signaling pathways. The vertical axis indicates the pathway, and the horizontal axis indicates the gene ratio (gene ratio is the ratio of the number of DEGs to the total number of DEGs annotated to the KEGG pathway). The size and color of the bubble represent the number of DEGs enriched in a pathway and the significance of enrichment, respectively. (C–F) (C) Relative expression level of inflammatory cytokines in WT, mutant and MT treatment brains (technical replicates, N = 4). Locomotor activity (D) biological replicates, N = 24), shoaling behavior (E) (biological replicates, N = 24) and three kinds of repetitive behaviors (F) (biological replicates, N = 24)) of WT, mutant and MC treatment zebrafish. NT was short for no treatment. Data are analyzed using unpaired t test and presented as the mean ± SEM, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 and ^****P < 0.0001. Source data are available online for this figure.

Expression Data

Genes:	il1b il6 tnfa
Fish:	nomo^{zf3952/zf3952}
Condition:	chemical treatment by environment: minocycline
Anatomical Term:	brain
Stage:	Days 45-89

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nomo^{zf3952/zf3952}
Condition:	chemical treatment by environment: minocycline
Observed In:	brain brain apoptotic process brain inflammatory response locomotory behavior social behavior swimming behavior
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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