FIGURE

Fig. 4

ID

ZDB-FIG-240215-4

Publication

Desalegn et al., 2023 - Perinatal exposure to potential endocrine disrupting chemicals and autism spectrum disorder: From Norwegian birth cohort to zebrafish studies

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Fig. 4

Effects of ?-HCH on early developmental stage zebrafish larvae. A) Distribution of larval posture at 3 days post fertilization after exposure to ?-HCH in early developmental stages. B) Distribution of larval touch response at 3 days post fertilization after exposure to ?-HCH. Significance was calculated using Chi-square test. C) Effect of ?-HCH on shoaling behavior in 7 days post fertilization larvae. 0 ng/mL control: N = 9; 29 ng/mL: N = 9; 290 ng/mL: N = 7; 29 ?g/mL: N = 10. Error bars represent S.E.M., significance was calculated using one-way ANOVA with Dunnett?s post-test. D) Effect of ?-HCH on cell proliferation in the optic tectum of 5 days post fertilization larvae. BrdU signal labelling proliferating cells was normalised to the mean of vehicle treated larvae and log transformed. 0 ng/mL control: N = 17; 29 ng/mL: N = 9; 290 ng/mL: N = 10. 0.06 ng/mL ?-HCH: N = 11; 0.29 ng/mL ?-HCH: N = 9; 0.18 ng/mL BDE-28: N = 14, 0.86 ng/mL BDE-28: N = 11. Error bars represent S.E.M., significance was calculated using a Kruskal-Wallis H test with Dunn?s post-test. E) Representative images of BrdU staining in optic tectum of 5 days post fertilization larvae after ?-HCH treatment. Red: BrdU-labeled proliferating cells, cyan: nuclear staining. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: beta-hexachlorocyclohexane
Observed In:	neuromuscular process controlling posture optic tectum cell population proliferation social behavior thigmotaxis
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

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