FIGURE

Fig. 7

ID

ZDB-FIG-231121-66

Publication

Zhang et al., 2023 - Novel biallelic variants in the PLEC gene are associated with severe hearing loss

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Plectin knockdown results in abnormal hair cell synapses. A-L: Representative images of 3dpf Tg(NeuroD-GFP) neuromasts from scrambled (A-C), plectin a (D-F), plectin b (G-I), plectin a + b (J-L) morphants. Samples were immunostained for the pre-synaptic marker, ribeye B (red), the post-synaptic marker, MAGUK (magenta), and the afferent neuronal marker, GFP (green). Scale bar: 5 μm. M-O: Violin plots comparing the number of pre-synaptic puncta (M), post-synaptic puncta (N) and ribbon synapses (O) in the different groups. Each dot represents the number of puncta per neuromast, with at least two neuromasts inspected per fish, and between 6 and 10 fish inspected. One-way ANOVA followed by Dunnett T3 multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Hearing Research, 436, Zhang, T., Xu, Z., Zheng, D., Wang, X., He, J., Zhang, L., Zallocchi, M., Novel biallelic variants in the PLEC gene are associated with severe hearing loss, 108831108831, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.