FIGURE

Fig. 3

ID

ZDB-FIG-231121-62

Publication

Zhang et al., 2023 - Novel biallelic variants in the PLEC gene are associated with severe hearing loss

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Fig. 3

Tertiary structure prediction of wild type and mutant plectin in family #1. A-F: Sequence homology-based prediction approach of the 770 amino acid sequence encompassing the mutation E2266L. G-J: Sequence homology-based prediction approach of the 530 amino acid sequence encompassing the mutation R4243H. The 3D structure was predicted from the condensing complex from S. cerevisiae employing Phyre2 free tool. Amino acids are colored code in a gradient from red (N-terminus) to yellow (C-terminus).The amino acid of interest in colored in green. Wild type rod domain (A-C), mutant rod domain (D-F), wild type 5th and 6th plectin repeat domains (G-H), mutant 5th and 6th repeat domains (I-J).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Hearing Research, 436, Zhang, T., Xu, Z., Zheng, D., Wang, X., He, J., Zhang, L., Zallocchi, M., Novel biallelic variants in the PLEC gene are associated with severe hearing loss, 108831108831, Copyright (2023) with permission from Elsevier. Full text @ Hear. Res.