ZFIN Morpholino: MO1-plecb

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-plecb

No data available

Phenotype

Phenotype resulting from MO1-plecb

Phenotype	Fish	Figures
locomotion disrupted, abnormal	WT + MO1-plecb	Fig. 2 from Bührdel et al., 2015
neuromast ribbon synapse decreased amount, abnormal	nl1Tg + MO1-plecb	Fig. 7 from Zhang et al., 2023
neuromast hair cell mitochondrion decreased functionality, abnormal	nl1Tg + MO1-plecb	Fig. 8 from Zhang et al., 2023
neuromast hair cell postsynapse ab1-pan-maguk labeling decreased amount, abnormal	nl1Tg + MO1-plecb	Fig. 7 from Zhang et al., 2023
neuromast hair cell presynapse ab4-ctbp2l labeling decreased amount, abnormal	nl1Tg + MO1-plecb	Fig. 7 from Zhang et al., 2023
pericardium edematous, abnormal	WT + MO1-plecb	Fig. S4 from Bührdel et al., 2015
skeletal muscle refractivity, abnormal	WT + MO1-plecb	Fig. S4 from Bührdel et al., 2015
skeletal muscle nucleus circular, abnormal	WT + MO1-plecb	Fig. 3 from Bührdel et al., 2015
skeletal muscle sarcomere disorganized, abnormal	WT + MO1-plecb	Fig. 3 from Bührdel et al., 2015
thigmotaxis disrupted, abnormal	WT + MO1-plecb	Fig. 2 from Bührdel et al., 2015
trunk curved, abnormal	WT + MO1-plecb	Fig. S4 from Bührdel et al., 2015
whole organism decreased mobility, abnormal	WT + MO1-plecb	Fig. 2 from Bührdel et al., 2015

Phenotype of all Fish created by or utilizing MO1-plecb

Phenotype	Fish	Conditions	Figures
skeletal muscle sarcomere disorganized, abnormal	WT + MO1-plecb	standard conditions	Fig. 3 from Bührdel et al., 2015
thigmotaxis disrupted, abnormal	WT + MO1-plecb	standard conditions	Fig. 2 from Bührdel et al., 2015
pericardium edematous, abnormal	WT + MO1-plecb	standard conditions	Fig. S4 from Bührdel et al., 2015
whole organism decreased mobility, abnormal	WT + MO1-plecb	standard conditions	Fig. 2 from Bührdel et al., 2015
skeletal muscle nucleus circular, abnormal	WT + MO1-plecb	standard conditions	Fig. 3 from Bührdel et al., 2015
locomotion disrupted, abnormal	WT + MO1-plecb	standard conditions	Fig. 2 from Bührdel et al., 2015
trunk curved, abnormal	WT + MO1-plecb	standard conditions	Fig. S4 from Bührdel et al., 2015
skeletal muscle refractivity, abnormal	WT + MO1-plecb	standard conditions	Fig. S4 from Bührdel et al., 2015
neuromast ribbon synapse decreased amount, abnormal	nl1Tg + MO1-plecb	standard conditions	Fig. 7 from Zhang et al., 2023
neuromast hair cell postsynapse ab1-pan-maguk labeling decreased amount, abnormal	nl1Tg + MO1-plecb	standard conditions	Fig. 7 from Zhang et al., 2023
neuromast hair cell presynapse ab4-ctbp2l labeling decreased amount, abnormal	nl1Tg + MO1-plecb	standard conditions	Fig. 7 from Zhang et al., 2023
neuromast hair cell mitochondrion decreased functionality, abnormal	nl1Tg + MO1-plecb	control	Fig. 8 from Zhang et al., 2023
neuromast hair cell presynapse ab4-ctbp2l labeling decreased amount, abnormal	nl1Tg + MO1-pleca + MO1-plecb	standard conditions	Fig. 7 from Zhang et al., 2023
neuromast hair cell mitochondrion decreased functionality, abnormal	nl1Tg + MO1-pleca + MO1-plecb	control	Fig. 8 from Zhang et al., 2023

Citations

Include unpublished citations

Zhang, T., Xu, Z., Zheng, D., Wang, X., He, J., Zhang, L., Zallocchi, M. (2023) Novel biallelic variants in the PLEC gene are associated with severe hearing loss. Hearing Research. 436:108831108831
Bührdel, J.B., Hirth, S., Keßler, M., Westphal, S., Forster, M., Manta, L., Wiche, G., Schoser, B., Schessl, J., Schröder, R., Clemen, C.S., Eichinger, L., Fürst, D.O., van der Ven, P.F., Rottbauer, W., Just, S. (2015) In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochemical and Biophysical Research Communications. 461(2):217-23

1 - 2 of 2

Show