FIGURE

Figure 4—figure supplement 1.

ID

ZDB-FIG-231013-16

Publication

Simon et al., 2023 - Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

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Figure 4—figure supplement 1.

Close-up view of the region surrounding the mutated catalytic glutamate side chain (brown sticks) and D-loop residues zT575 (orange sticks) and zH576 (magenta sticks) in the cryo-EM structure of zCFTR-E1372Q, solved in the OF conformation (PDBID: 5w81).

Purple dotted line illustrates suggested H-bond between the zT575 side chain and the backbone carbonyl oxygen of zA1375 (green sticks).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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