Image
Figure Caption

Figure 4—figure supplement 1. Close-up view of the region surrounding the mutated catalytic glutamate side chain (brown sticks) and D-loop residues zT575 (orange sticks) and zH576 (magenta sticks) in the cryo-EM structure of zCFTR-E1372Q, solved in the OF conformation (PDBID: 5w81).

Purple dotted line illustrates suggested H-bond between the zT575 side chain and the backbone carbonyl oxygen of zA1375 (green sticks).

Acknowledgments
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