FIGURE

Fig. 5.

ID

ZDB-FIG-231002-70

Publication

Leid et al., 2023 - Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism

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Fig. 5.

cora^stl325 is a null allele of taf5. (A) Brightfield images of control, cora^stl325, taf5^stl852, and cora^stl325/ taf5^stl852 embryos at 96 hpf. (B) Measurement of pericardial area and ejection fraction in control, cora^stl325, taf5^stl852, and cora^stl325/ taf5^stl852 embryos at 96 hpf. n=22. (C) Measurement of head-to-body and head-to-eye ratios in control, cora^stl325, taf5^stl852, and cora^stl325/ taf5^stl852 embryos at 96 hpf. n=22. (D) Survival of control, taf5^stl852, and cora^stl325/taf5 CRISPR embryos. n=42. (E) RTPCR for taf5 mRNA in control, cora^stl325, taf5^stl852, and cora^stl325/ taf5^stl852 embryos at 96 hpf. n=7. (F) Time course of taf5 mRNA expression by whole-mount in situ hybridization (top) and taf5 mRNA expression in cora^stl325 and taf5^stl852 embryos at 96 hpf. Note: all brackets marked with ‘*’ represent P<1E-4.

Expression Data

Gene:	taf5
Fish:	WT taf5^{stl325/stl325} taf5^{stl852/stl852}
Anatomical Terms:	head heart heart tube whole organism
Stage Range:	Prim-5 to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	taf5^{stl325/stl325} taf5^{stl852/stl852}
Observed In:	cranial skeletal system development head heart pericardium whole organism
Stage Range:	Day 4 to Days 14-20

Phenotype Detail

Acknowledgments

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