Fig. 11
Fig. 11. The protein changes induced by SMCE and SMHF during the melanogenesis process of zebrafish. The decrease in keratin, actin, and EF-1a might have caused deformation and depigmentation of RPE in zebrafish embryos, giving rise to pale eye colour. In the meantime, the downregulation of cathepsin LB by SMCE and SMHF could be a factor in the decrease of melanin production in the body of the zebrafishes. The green arrows represent the downregulation of expression by either SMCE or SMHF, whereas the red arrows represent genes that were upregulatd. The dashed lines are proposed interconnected pathways that might have been activated during treatment. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) |