FIGURE

Fig. 2

ID

ZDB-FIG-230707-43

Publication

Dinarello et al., 2023 - STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

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Fig. 2

STAT3 physically interacts with HIF1α.

A RT-qPCR analysis of Hif1α mRNA expression on murine Stat3^+/+ and Stat3^−/− murine ESCs incubated either in low and in high oxygen tensions. B, C western blot analysis of HIF1α and STAT3 from protein extracts of Stat3^+/+ and Stat3^−/− murine ESCs incubated either in low and in high oxygen tensions. Representative pictures (B) and quantifications (C). β-Actin was used as an internal control. 3 independent biological replicates were used. D PLA with anti-STAT3 and anti-HIF1α antibodies. Scale bar = 200 μm. Quantification of dots divided for the number of nuclei detected with DAPI (blue). n = 3 independent biological replicas were used. Scale bar = 200 μm. Mean ± SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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