FIGURE

FIGURE 2

ID

ZDB-FIG-230307-21

Publication

Kim et al., 2023 - EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B

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FIGURE 2

The EWSR1 knockdown promotes induction of lagging chromosome during anaphase. (A). Schematic diagram for the mitotic synchronization of EWSR1 knockdown cells using Thymidine and Nocodazole, followed by the mitotic shake-off and release from the mitotic arrest for 60 min. (B). Representative images of chromosomes; normal (top panel), lagging chromosome (middle panel) and chromosome bridge (bottom panel). Yellow square highlights the magnified images of either lagging chromosome or chromosome bridge. Chr.; chromosome, Scale bar = 10 um. (C). Percentages of anaphase cells with lagging chromosomes (left graph) and of chromosomal bridges (right graph) in AUX- and AUX + cells (Total 34-104 anaphase cells per sample, n = 3 experiments). *p < 0.05. (paired t-test), NS; Non-Significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol