FIGURE

FIGURE 7

ID

ZDB-FIG-230307-26

Publication

Kim et al., 2023 - EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B

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FIGURE 7

The interaction between EWSR1 and Aurora B prevents the induction of aneuploidy. (A). The high incidence of aberrant chromosome numbers in AUX+/DOX-treated cells was rescued by the expression of EWSR1 overexpression (AUX+/DOX+) cells (28-59 cells per sample, n = 3 experiments). One-way ANOVA with Tukey multiple comparison test., **p < 0.01, *p < 0.05. NS = Non-significant. (B). The percentages of cells with each chromosome numbers in AUX-/DOX- (n = 122), AUX+/DOX- (n = 117), and AUX+/DOX+(n = 106) cells. (C). The high incidence of aberrant chromosome numbers in AUX+/DOX-cells was not rescued by the expression of EWSR1:R565A in AUX+/DOX + cells. (35-42 cells per sample, n = 6 experiments, One-way ANOVA with Tukey multiple comparison test. *p < 0.05, NS = non-significant. (D). The percentage of cells with each chromosome number in AUX-/DOX- (n = 221), AUX+/DOX- (n = 228), and AUX+/DOX+(n = 219) cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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