FIGURE

Figure 7

ID

ZDB-FIG-230110-103

Publication

Gabellini et al., 2022 - CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish

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Figure 7

setd5 haploinsufficiency affects mRNA expression levels of synaptic regulators. (a,b) Expression of homer1b-202 (a) and dyrk1aa (b) in setd5+/+ and setd5+/− adult zebrafish brains, obtained by RT-qPCR analysis. The values are expressed as 2^−(ΔCt), using bactin1 as the housekeeping gene. n = number of adult brains analyzed. Data are expressed as mean ± SEM. Statistical analysis was performed using a Student’s t-test. * p < 0.05. (c–j) Linear regression analysis between setd5 wild type mRNA level and gad1a/GAD67 (c), vesicular monoamine transporter 2 (d), sertA (e), synaptophysin a (f), tyrosine hydroxylase 1 (g), histidine decarboxylase (h), dopa decarboxylase (i), and shank3B (j) in setd5+/+ (empty dots) and setd5+/− (full dots) adult zebrafish brains, obtained by RT-qPCR analysis. R² = coefficient of determination. A linear regression-fitting curve is shown.

Expression Data

Genes:	dyrk1aa homer1b
Fish:	setd5^zf3885/+
Anatomical Term:	brain
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	setd5^zf3885/+
Observed In:	brain
Stage:	Adult

Phenotype Detail

Acknowledgments

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