FIGURE

Figure 5

ID

ZDB-FIG-230110-101

Publication

Gabellini et al., 2022 - CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish

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Figure 5

setd5 haploinsufficiency alters locomotor activity and induces an anxiety-like shoaling behavior in adult mutant zebrafish. (a) Distance moved and (b) speed (cm/s) of setd5+/+ and setd5+/− adult fish evaluated during a 5-min-long open field test.; n = number of fishes analyzed. (c) Nearest Neighbor Distance (NND), (d) Inter-Individual Distance (IID), (e) polarization and (f) mean speed of fish groups constituted by 4 setd5+/+ or setd5+/− adults, evaluated by a shoaling test. (a–f) n = number of group of fish analyzed. Data are expressed as mean ± SEM. Statistical analysis was performed by Student’s t-test. * p < 0.05; *** p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	setd5^zf3885/+
Observed In:	larval locomotory behavior locomotory exploration behavior social behavior
Stage Range:	Day 6 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.