FIGURE

Figure 1

ID

ZDB-FIG-230110-97

Publication

Gabellini et al., 2022 - CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish

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Figure 1

setd5 is expressed in the zebrafish adult brain and at early stages of zebrafish embryo development. (a) setd5-203 isoform localization on zebrafish WT brain sections at 10/12 months of age performing in situ hybridization technique. Representative images of a section corresponding to telencephalon (1–3), diencephalon-mesencephalon (4,5) and rhombencephalon (6), n = 3 brains analyzed. Scale bar 300 µm. (b) Expression of setd5 isoforms in zebrafish embryos and larvae at different developmental stages, obtained by RT-qPCR analysis. Data are expressed as 2^−(ΔCt) mean ± Standard Error of the Mean (SEM), using b-actin1 as housekeeping gene. n = 3 independent experiments. Abbreviations: D, Dorsal telencephalic area; V, Ventral telencephalic area; OB, Olfactory bulb; LOT, Lateral olfactory tract; Ppa, Parvocellular preoptic nucleus; TL, Longitudinal Torus; Val, Lateral division of valvular cerebelli; TeO, Tectum opticum; PGZ, Periventricular gray zone of optic tectum; DTN, Dorsal tegmental nucleus; HV, Ventral zone of periventricular hypothalamus; PTN, Posterior tuberal nucleus; PGm, Medial progromerular nucleus; DIL, Diffuse nucleus of the inferior lobe; Hc, Caudal zone of periventricular hypothalamus; Hd, Dorsal zone of the periventricular hypothalamus; CCe, Cerebellar corpus; LCa, Caudal lobe of cerebellum; LVII, Facial lobe; ALLN, Anterior lateral line nerves; VIII, Octaval nerve; hpf, hours post fertilization

Expression Data

Gene:	setd5
Fish:	WT
Anatomical Terms:	caudal periventricular hypothalamus caudal tuberal nucleus cranial nerve VIII diffuse nucleus inferior lobe dorsal telencephalon facial lobe lateral olfactory tract medial preglomerular nucleus olfactory bulb parvocellular preoptic nucleus torus longitudinalis valvula cerebelli ventral hypothalamic zone ventral telencephalon whole organism
Stage Range:	1-cell to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.