Gene

dyrk1aa

ID
ZDB-GENE-050302-29
Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
Symbol
dyrk1aa Nomenclature History
Previous Names
  • dyrk1a
  • im:6962097
  • zgc:158359
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in angiogenesis and brain development. Predicted to localize to nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dyrk1aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 7 Alliance Mental retardation, autosomal dominant 7 614104
Associated With dyrk1aa Via Experimental Models
Human Disease Fish Conditions Citations
autism spectrum disorder dyrk1aakrb1/krb1 standard conditions (2)
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR044131 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Family IPR028318 Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain Dual specificity tyrosine-phosphorylation-regulated kinase 1A/B Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:E9QHB0 226
UniProtKB:A0A2R8QF25 733
UniProtKB:A1L1U2 737
UniProtKB:E9QFG0 222
UniProtKB:F1QSN1 737
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations