Gene

dyrk1aa

ID

ZDB-GENE-050302-29

Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a

Symbol

dyrk1aa Nomenclature History

Previous Names

dyrk1a
im:6962097
zgc:158359

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and transcription coactivator activity. Involved in angiogenesis and brain development. Predicted to localize to nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dyrk1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder, autosomal dominant 7	614104

Associated With dyrk1aa Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	dyrk1aa^krb1/krb1	standard conditions	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR044131	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M1P9M8 InterPro	733
UniProtKB:A1L1U2 InterPro	737

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dyrk1aa-201 (1) Ensembl	Ensembl	2214 nt	Select Tool ZFIN BLAST
mRNA	dyrk1aa-203 (1) Ensembl	Havana	695 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dyrk1aa-204 (1) Ensembl	Havana	1216 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dyrk1aa-206 (1) Ensembl	Ensembl	3573 nt	Select Tool ZFIN BLAST
ncRNA	dyrk1aa-003 (1) Ensembl	Havana	424 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	dyrk1aa-004 (1) Ensembl	Havana	574 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:192741

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations