Gene
dyrk1aa
- ID
- ZDB-GENE-050302-29
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
- Symbol
- dyrk1aa Nomenclature History
- Previous Names
-
- dyrk1a
- im:6962097
- zgc:158359
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within angiogenesis and brain development. Predicted to be active in nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 7 | Alliance | Intellectual developmental disorder, autosomal dominant 7 | 614104 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | dyrk1aakrb1/krb1 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P9M8
|
733 | ||||||
|
UniProtKB:A1L1U2
|
737 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1aa-201
(1)
|
Ensembl | 2,214 nt | ||
| mRNA |
dyrk1aa-203
(1)
|
Ensembl | 695 nt | ||
| mRNA |
dyrk1aa-204
(1)
|
Ensembl | 1,216 nt | ||
| mRNA |
dyrk1aa-206
(1)
|
Ensembl | 3,573 nt | ||
| ncRNA |
dyrk1aa-003
(1)
|
Ensembl | 424 nt | ||
| ncRNA |
dyrk1aa-004
(1)
|
Ensembl | 574 nt |
Interactions and Pathways
No data available
Plasmids