Gene
dyrk1aa
- ID
- ZDB-GENE-050302-29
- Name
- dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
- Symbol
- dyrk1aa Nomenclature History
- Previous Names
-
- dyrk1a
- im:6962097
- zgc:158359
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within angiogenesis and brain development. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; endothelial cell; eye; heart; and spinal cord. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15575 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21625 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27522 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| y656 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ya513 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ya514 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| krb1 | Allele with one deletion | Exon 5 | Frameshift, Premature Stop | TALEN |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dyrk1aa | (2) | |
| CRISPR2-dyrk1aa | (2) | |
| CRISPR3-dyrk1aa | (2) | |
| TALEN1-dyrk1aa | (5) |
1 - 4 of 4
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 7 | Alliance | Intellectual developmental disorder, autosomal dominant 7 | 614104 |
1 - 1 of 1
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | dyrk1aakrb1/krb1 | standard conditions | (2) |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR044131 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain |
| Family | IPR050494 | Serine/threonine and dual-specificity kinase |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine and dual-specificity kinase | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P9M8 | InterPro | 733 | ||||||
| UniProtKB:A1L1U2 | InterPro | 737 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dyrk1aa-201
(1)
|
Ensembl | 2,214 nt | ||
| mRNA |
dyrk1aa-203
(1)
|
Ensembl | 695 nt | ||
| mRNA |
dyrk1aa-204
(1)
|
Ensembl | 1,216 nt | ||
| mRNA |
dyrk1aa-206
(1)
|
Ensembl | 3,573 nt | ||
| ncRNA |
dyrk1aa-003
(1)
|
Ensembl | 424 nt |
1 - 5 of 6 Show all
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-446E18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6962097 | ||
| Encodes | cDNA | MGC:158359 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001347739 (1) | 3573 nt | ||
| Genomic | GenBank:CU633885 (1) | 40556 nt | ||
| Polypeptide | UniProtKB:A1L1U2 (1) | 737 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Wellalage Don, D., Kim, T.Y., Hong, B.N., Lee, J.S., Kang, T.H., Gerlai, R., Kim, C.H. (2024) A Simple Tube Escape Assay to Test Learning and Memory in Zebrafish with Minimized Habituation. Zebrafish. 21(5):329-337
- Weinschutz Mendes, H., Neelakantan, U., Liu, Y., Fitzpatrick, S.E., Chen, T., Wu, W., Pruitt, A., Jin, D.S., Jamadagni, P., Carlson, M., Lacadie, C.M., Enriquez, K.D., Li, N., Zhao, D., Ijaz, S., Sakai, C., Szi, C., Rooney, B., Ghosh, M., Nwabudike, I., Gorodezky, A., Chowdhury, S., Zaheer, M., McLaughlin, S., Fernandez, J.M., Wu, J., Eilbott, J.A., Vander Wyk, B., Rihel, J., Papademetris, X., Wang, Z., Hoffman, E.J. (2023) High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports. 42:112243112243
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Papenfuss, M., Lützow, S., Wilms, G., Babendreyer, A., Flaßhoff, M., Kunick, C., Becker, W. (2022) Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B. Scientific Reports. 12:2393
- Buchberger, A., Schepergerdes, L., Flaßhoff, M., Kunick, C., Köster, R.W. (2021) A novel inhibitor rescues cerebellar defects in a zebrafish model of Down Syndrome-associated kinase Dyrk1A overexpression. The Journal of biological chemistry. 297(1):100853
- Aslanzadeh, M., Ariyasiri, K., Kim, O.H., Choi, T.I., Lim, J.H., Kim, H.G., Gerlai, R., Kim, C.H. (2019) The Body Size of Stimulus Conspecifics Affects Social Preference in a Binary Choice Task in Wild-Type, But Not in dyrk1aa Mutant, Zebrafish. Zebrafish. 16(3):262-267
- Cho, H.J., Lee, J.G., Kim, J.H., Kim, S.Y., Huh, Y.H., Kim, H.J., Lee, K.S., Yu, K., Lee, J.S. (2019) Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish. Disease models & mechanisms. 12(5):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
1 - 10 of 16
Show