FIGURE

Figure 8

ID

ZDB-FIG-221211-28

Publication

Forte-Gomez et al., 2022 - Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta

Other Figures

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Figure 8

Electron microscopy of myosepta in wild type and mutant ΔI258D259Comp skeletal muscle of 72hpf zebrafish. The skeletal muscle fiber (MF) structure is comparable in wild type (wt) (A) and mutant ΔI258D259Comp (B) zebrafish while the myosepta (MS) in mutants are less dense and slightly enlarged compared to control. At higher magnification the myosepta of wild type (C) show a largely homogenous extracellular matrix (ECM) structure while myosepta of mutants (D) show disrupted (black asterisks), inhomogeneous and clustered ECM (arrows) structure with different density. The fibroblasts in wild type (E) and mutants (F) show an extensive endoplasmic reticulum (white asterisks) without obvious differences, indicating intact synthesis- active fibroblasts and no significant retention of mutant protein.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	comp^{zf3751/zf3751} (KOLN)
Observed In:	myoseptum myoseptum extracellular matrix skeletal muscle cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Endocrinol (Lausanne)