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Figure 8

ID: ZDB-IMAGE-221211-33
Publication: Forte-Gomez et al., 2022 - Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta
All Figures: Figures for Forte-Gomez et al., 2022

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Figure 8

Electron microscopy of myosepta in wild type and mutant ΔI258D259Comp skeletal muscle of 72hpf zebrafish. The skeletal muscle fiber (MF) structure is comparable in wild type (wt) (A) and mutant ΔI258D259Comp (B) zebrafish while the myosepta (MS) in mutants are less dense and slightly enlarged compared to control. At higher magnification the myosepta of wild type (C) show a largely homogenous extracellular matrix (ECM) structure while myosepta of mutants (D) show disrupted (black asterisks), inhomogeneous and clustered ECM (arrows) structure with different density. The fibroblasts in wild type (E) and mutants (F) show an extensive endoplasmic reticulum (white asterisks) without obvious differences, indicating intact synthesis- active fibroblasts and no significant retention of mutant protein.

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Phenotype details

Acknowledgments

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