FIGURE

Fig. 4

ID

ZDB-FIG-221119-30

Publication

Coffey et al., 2021 - Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix

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Fig. 4

Laminin receptor beta-dystroglycan is not required for laminin-111 protein re-expression at 3.5 dpf in spns1^?/? larvae. (A?F1) Anterior left, dorsal top, side-mounted embryos, and larvae. dag1^?/? and spns1^?/?; dag1^?/? embryos and larvae stained with phalloidin (white) and laminin-111(cyan), (A?F) Merged phalloidin and laminin-111 channels and (A1?F1) single beta-dystroglycan channel over time. (A?F) White arrowheads point to dystrophic lesions and (A1?F1) white arrowheads point to laminin-111 staining. (G) Relative laminin-111 fluorescent intensity over time in spns1^?/?; dag1^?/? embryos and larvae. Scale bars 50 µm.

Expression Data

Antibody:	Ab1-lam
Fish:	dag1^{hu3072/hu3072} dag1^{hu3072/hu3072}; spns1^{hi891Tg/hi891Tg}
Anatomical Term:	vertical myoseptum muscle tendon junction
Stage Range:	Long-pec to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dag1^{hu3072/hu3072}; spns1^{hi891Tg/hi891Tg}
Observed In:	vertical myoseptum muscle tendon junction
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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