FIGURE

Figure 7

ID

ZDB-FIG-221119-17

Publication

Leyhr et al., 2022 - A novel cis-regulatory element drives early expression of Nkx3.2 in the gnathostome primary jaw joint

Other Figures

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Figure 7

Geometric morphometric analysis of jaw joint regulatory sequence 1 (JRS1) deletion phenotypes at 9 dpf.

(A) Principal components analysis of geometric morphometric comparison of posterior Meckel’s cartilage shape in wild-type, nkx3.2^+/ΔJRS1, and nkx3.2^{ΔJRS1/ΔJRS1} zebrafish at 9 dpf. Thin-plate splines display the extremes of shape along PC1 and PC2. Inset is a histogram showing the percentage of variance explained by PCs 1–5. (B–G) Lateral and dorsal 3D renderings of the left jaw joint from averaged optical projection tomography (OPT) models of wild-type (N = 12), nkx3.2^+/ΔJRS1 (N = 10), and nkx3.2^{ΔJRS1/ΔJRS1} (N = 8) zebrafish at 9 dpf. White arrowheads mark the partial fusion between Meckel’s cartilage (m) and the palatoquadrate (pq). Black arrowhead marks the reduced retroarticular process (ra). Scale bars: 25 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nkx3-2^{uu3731/uu3731} nkx3-2^uu3731/+
Observed In:	Meckel's cartilage posterior margin Meckel's cartilage-palatoquadrate cartilage joint Meckel's cartilage-palatoquadrate cartilage joint embryonic skeletal joint morphogenesis palatoquadrate cartilage anterior margin retroarticular process
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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