FIGURE

Fig. 1

ID

ZDB-FIG-221101-19

Publication

Kugler et al., 2021 - The effect of absent blood flow on the zebrafish cerebral and trunk vasculature

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

The effect of tnnt2a morpholino knockdown on cerebral vessel development. (A, B, C and D) Cerebral vasculature from 2 to 5dpf in Tg(kdrl:HRAS-mCherry)^s916 uninjected animals. (E, F, G and H) Cerebral vasculature in control MO-injected animals. (I, J, K and L) Cerebral vasculature in tnnt2a MO injected animals (n = 7–10; two experimental repeats). The lack of blood flow in tnnt2a morphants perturbs vascular development and worsens over time. Comparison between treatment groups shows that the midbrain vasculature is severely affected in tnnt2a MO (dotted lines) and the PCV surrounding the OV is enlarged (filled arrowhead), while the PHBC appears normal (unfilled arrowhead; d – dorsal, v – ventral; representative images colour-coded by depth).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Vasc Biol