ZFIN Image: Kugler et al., 2021, Fig. 1

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Figure Caption

Fig. 1

The effect of tnnt2a morpholino knockdown on cerebral vessel development. (A, B, C and D) Cerebral vasculature from 2 to 5dpf in Tg(kdrl:HRAS-mCherry)^s916 uninjected animals. (E, F, G and H) Cerebral vasculature in control MO-injected animals. (I, J, K and L) Cerebral vasculature in tnnt2a MO injected animals (n = 7–10; two experimental repeats). The lack of blood flow in tnnt2a morphants perturbs vascular development and worsens over time. Comparison between treatment groups shows that the midbrain vasculature is severely affected in tnnt2a MO (dotted lines) and the PCV surrounding the OV is enlarged (filled arrowhead), while the PHBC appears normal (unfilled arrowhead; d – dorsal, v – ventral; representative images colour-coded by depth).

Acknowledgments

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