FIGURE

Fig. 7

ID

ZDB-FIG-221028-22

Publication

Cacialli et al., 2022 - Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates

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Fig. 7

The expression of the prostaglandin synthesis pathway is conserved between the zebrafish CHT and the mouse fetal liver

A, B
(A) Summary of prostaglandin gene expression pathways in the CHT of zebrafish, and (B) in mouse FL. The different symbols correspond to the C _t value to which the threshold of detection was applied during the analysis of the qPCR: very high expression (++++) C _t < 24; high expression (+++) 25 < C _t < 28; medium expression (++) 29 < C _t < 32; low expression (+) 33 < C _t < 36; very low to no expression (−) C _t > 37.
C
Proposal mechanism in which HSCs, ECs, macrophages and neutrophils cooperate in the embryonic niche. In normal conditions (upper panel) slco2b1 permits the transfer of PGE2 precursors in ECs. The deficiency of slco2b1 (lower panel) decreases PGE2 levels in the CHT niche, generating a defect of HSC proliferation.

Source data are available online for this figure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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