FIGURE

Fig. 4

ID

ZDB-FIG-220719-20

Publication

Morales Fénero et al., 2021 - Short chain fatty acids (SCFAs) improves TNBS-induced colitis in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

SCFAs decrease TNBS-induced inflammation. A. Representative images of the intestinal area (yellow dotted line) of Tg(lysC:DsRed2)^nz50 transgenic larvae after 72h (10 dpf) of 50 μg/mL (T50) and 75 μg/mL (T75) TNBS exposure and treated with 3 mM of SCFAs (SCFA3). Rostral to the left and dorsal up. Scale bar 200 μm. B. Graphical representation of the number of lysC: DsRed + cells (neutrophils) in the intestine of 10 dpf larvae. One-way ANOVA with Tukey's multiple comparisons. ****p < 0.0001. N = 7–26. C-E. Relative expression of il1b(C), il6(D), and tnfa(E), in whole larvae after 24, 48 and 72h of TNBS 50 μg/mL exposure and treated with SCFA 3 mM. Two-way ANOVA with Tukey's multiple comparisons. *p < 0.05; **p < 0.01; ***p < 0.001; ***p < 0.0001. N = 4–7. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Expression Data

Genes:	il1b il6
Fish:	nz50Tg
Conditions:	chemical treatment by environment: 2,4,6-trinitrobenzenesulfonic acid chemical treatment by environment: short-chain fatty acid
Anatomical Term:	whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB nz50Tg
Conditions:	chemical treatment by environment: 2,4,6-trinitrobenzenesulfonic acid chemical treatment by environment: short-chain fatty acid
Observed In:	gut neutrophil whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Curr Res Immunol