FIGURE

Fig. 1

ID
ZDB-FIG-220623-63
Publication
Silvennoinen et al., 2022 - SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility
Other Figures
All Figure Page
Back to All Figure Page
Fig. 1

rs7587026 genotype is correlated with SCN1A expression in individuals with MTLEHS, whereas rs922224 genotype is not. a,b Violin plots showing the expression levels of SCN1A in hippocampi of individuals with MTLEHS stratified by SNP genotype. Horizontal lines within the plots present median and quartiles. a Individuals with MTLEHS homozygous for the minor allele (rs7587026) have higher SCN1A expression levels compared to the other two genotypes (CC: n = 43, CA: n = 40, AA: n = 8; Kruskal–Wallis test: **P = 0.004, Dunn’s test: CC vs. AA: **P = 0.003, CA vs. AA: *P = 0.035). b No differences in SCN1A expression levels were observed by rs922224 genotype in MTLEHS (AA: n = 33, AG: n = 46, GG: n = 12; Kruskal–Wallis test: P = 0.226). See Supplementary Table 3 (online resource) for the expression level values

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Acta Neuropathol.