Figure 5

T2‐weighted images of two xenografted tumors taken at day 0 and 21 (largest diameter). The tumors are representative of the two treatment groups Scale bar: 2 mm.

Changes in tumor volumes as determined by MRI were normalized to the day 0 value (= 100%) for each animal. All box plots show 25^th to 75^th percentiles (box) and 5^th to 95^th percentiles (whiskers). The line in the box represents the median. **P = 0.007 (one way ANOVA).

Changes in tumor volumes in female rats treated with AMG386 (n = 6) or with placebo (n = 5) for 14 days as determined by anatomical MRI, normalized to the day 0 value. Box plots show 25^th to 75^th percentiles (box) and 5^th to 95^th percentiles (whiskers). The line in the box represents the median. P = 0.0673, not significant (one way ANOVA).

ADC values of the rat PitNETs before (day 0) and after (day 14) treatment with AMG386 (red, n = 8) or placebo (blue, n = 5). Box plots show 25^th to 75^th percentiles (box) and 5^th to 95^th percentiles (whiskers). The line in the box represents the median. **P = 0.009; n.s., not significant (t‐test).

Ex vivo expression of Tie2, P‐Tie2, Ki67 and Annexin V in PitNETs of female rats treated with AMG386 or placebo for 14 days. Original magnification: 200×; scale bar: 50 µm. Panels shown are representative of the two animal groups.

Quantification of Annexin V intensity from tissues stained as in (F) (n = 4/group). Three different areas per tumor sample were analyzed. Intensities are expressed as arbitrary units ± SEM. ***P < 0.001 (by t‐test).