FIGURE

Figure 6

ID

ZDB-FIG-220516-10

Publication

Karabid et al., 2022 - Angpt2/Tie2 autostimulatory loop controls tumorigenesis

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Figure 6

Tumor/endothelial cells crosstalk in the tumor microenvironment (TME)

Pituitary tumor cells secrete mostly Angpt2 in the TME. Tumor‐associated ECs secrete mostly Angpt2 but also Angpt1. Thanks to the expression of Tie2 on their plasma membrane, tumor cells can respond to angiopoietins (secreted by both tumor and endothelial cells) and activate pro‐proliferative/pro‐survival pathways.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ EMBO Mol. Med.