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Figure 6
Pituitary tumor cells secrete mostly Angpt2 in the TME. Tumor‐associated ECs secrete mostly Angpt2 but also Angpt1. Thanks to the expression of Tie2 on their plasma membrane, tumor cells can respond to angiopoietins (secreted by both tumor and endothelial cells) and activate pro‐proliferative/pro‐survival pathways.
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Full text @ EMBO Mol. Med.