FIGURE

Fig. 8

ID

ZDB-FIG-220511-29

Publication

Nagabhishek et al., 2019 - A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling

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Fig. 8

(A) Shows the representation of rats for 4 different groups of experimental rats and (B) the mammary gland morphology for all the groups. Where the control group 1 control shows normal breast morphology and group 2 DMBA induced group shows an incased tumor formed group 3 monacolin X treated post tumor induction and group 4 SU5416 treated group. Whereas the graphs (C) post treatment with monacolin X and SU5416 shows reduction in the tumor weight (gm) and volume (mm³), body weight (gm) and tumor incidence (%). (D) Shows the immunohistochemical analysis for tumor angiogenesis and survival status via pVEGFR2 and pAKT1 expression were significantly increased in the group 2 (DMBA) when compared to group 1, the treated group 3 and 4 (DMBA + monacolin X) (DMBA + SU5416) showed decreased expression levels of these proteins. The results were taken under (10×) magnification and the results were represented as mean ± SD (n = 3); ***p < 0.001 when compared with DMBA group. (E) Shows the histogram for the number of positive cells for pVEGFR2 and pAKT1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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