FIGURE

Fig. 4

ID

ZDB-FIG-220511-25

Publication

Nagabhishek et al., 2019 - A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling

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Fig. 4

Represents panel of transgenic Tg(Kdr:EGFP)/ko1 zebrafish embryos that show green fluorescent protein (GFP) expression in endothelial cells. (A) Fluorescent images of ISV in the zebrafish embryos incubated with 0.1% DMSO (Ctrl: vehicle-control), (B–E) monacolin X 3 nm, 6 nm, 0.5 μM and 1 μM for 48 h. (F) SU5416 was used as the positive control. Yellow arrow: deformed ISV. (G) Average ISV length in (μm) and average diameter (μm). (H) Shows SIV basket stretching into the posterior yolk extension in case of control and while in monacolin X and SU5416 treatment showed significant reduction in SIV length, diameter and number of SIV. Quantification of ISV and SIV area was determined by using the NIH Image J program. (I) Shows average SIV length in (μm) and average diameter (μm) and number of SIV. All values are presented as means ± SD (n = 6). **p < 0.01, ***p < 0.001 compared with control (one-way ANOVA).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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