FIGURE

FIGURE 4

ID

ZDB-FIG-220406-15

Publication

Zhou et al., 2022 - Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

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FIGURE 4

Effects of aconitine on TH, MAO, DAT and VMAT2 expressions in zebrafish larvaes and SH-SY5Y cells. (A) The mRNA expressions of th, mao, dat, vmat2 with aconitine exposure in zebrafish larvaes, n = 6. (B) TH and VMAT2 positive cells were investigated using immunostaining and Tg (vmat2:GFP) transgenic zebrafish larvaes, respectively, n = 5. (C) Effect of different exposure times of 1 μM aconitine on the protein expression of TH, n = 4. (D) The protein levels of TH, MAO-B, DAT and VMAT2 with aconitine exposure in zebrafish larvaes, n = 4. (E) The mRNA expressions of th, mao-b, dat, vmat2 with aconitine exposure in SH-SY5Y cells, n = 3. (F) The protein levels of TH, MAO-B, DAT, and VMAT2 with aconitine exposure in SH-SY5Y cells, n = 7. All photographs in which the green fluorescence represented the immune-reactive cells were taken under a confocal microscope (100×). The values are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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