FIGURE

FIGURE 5

ID

ZDB-FIG-220406-16

Publication

Zhou et al., 2022 - Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

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FIGURE 5

Regulation of DR-mediated AC/cAMP/PKA signalling pathway by aconitine in zebrafish larvaes and SH-SY5Y cells. (A) Expression of DR mRNA with aconitine exposure in zebrafish larvaes, n = 3. (B) D1R, D2R, AC, p-PKA, and PKA protein expressions with aconitine exposure in zebrafish larvaes, n = 7. (C) The cAMP contents were examined with aconitine exposure by ELISA assays in zebrafish larvaes, n = 3. (D) Changes of intracellular Ca²⁺ after treatment with aconitine in zebrafish larvaes, n = 5. (E) Expression of DR mRNA with aconitine exposure in SH-SY5Y cells, n = 5. (F) D1R, D2R, AC, p-PKA and PKA protein expressions with aconitine exposure in SH-SY5Y cells, n = 5. (G) The cAMP contents were examined with aconitine exposure by ELISA assays in SH-SY5Y cells, n = 3. All photographs were taken under a confocal microscope (100×). The values are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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