FIGURE

FIGURE 7

ID

ZDB-FIG-220205-22

Publication

Song et al., 2022 - Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks Follicle Activation in Zebrafish Ovary

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FIGURE 7

Loss of MAPK signaling response to EGF in egfra mutant ovary. (A) EGF treatment of ovarian fragments in vitro induced phosphorylation of MAPK3/1 (Erk1/2) in egfra+/− but not egfra−/− follicles. However, the mutant ovary showed higher basal level of MAPK phosphorylation despite its lack of response to EGF. (B) Immunohistochemical staining for MAPK3/1 phosphorylation in the control and mutant ovaries without EGF treatment. High level of phosphorylated MAPK3/1 was located in the somatic follicle cells of the egfra−/− ovary. (C) Increased expression of chemokine ligands (ccl25b, ccl34b.1, ccl34b.8, and ccl35.2) in egfra−/− follicles.

Expression Data

Genes:	ccl25b ccl34b.1 ccl34b.8 ccl35.2
Antibody:	Ab9-mapk
Fish:	egfra^umo21/umo21 (AB)
Anatomical Terms:	ovarian follicle ovarian follicle somatic cell
Stage:	Days 45-89

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	egfra^umo21/umo21 (AB)
Observed In:	ovarian follicle ovarian follicle somatic cell
Stage:	Days 45-89

Phenotype Detail

Acknowledgments

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