FIGURE

Fig. 9

ID

ZDB-FIG-211216-262

Publication

Hseu et al., 2021 - The in vitro and in vivo depigmenting activity of pterostilbene through induction of autophagy in melanocytes and inhibition of UVA-irradiated α-MSH in keratinocytes via Nrf2-mediated antioxidant pathways

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Fig. 9

Pt suppressed PI3K/AKT/mTOR pathway and dysregulated the Beclin-1/Bcl-2 and Bax/Bcl-2 ratios in B16F10 cells. Inhibitory effects of Pt in B16F10 cells. Different concentrations of Pt (0?30 ?M, 8 or 24 h) were treated to the cells. The Western blot technique determined the p-PI3K, PI3K (8 h), p-AKT, AKT (8 h), p-mTOR, mTOR (8 h) (A?D) or Beclin-1, Bcl-2, Bax (24 h) (E?F) proteins. Data were denoted as fold differences between phosphorylated and non-phosphorylated forms of PI3K (B), AKT (C), or mTOR (D) proteins. In Beclin-1, Bcl-2, Bax proteins, data were denoted as fold ratio between Beclin/Bcl-2 (E) or Bax/Bcl-2 (F). The ?-actin functioned as a loading control. Results were denoted as mean � SD of three or more independent experiments. Statistical significance was considered as **p < 0.01, ***p < 0.001 compared to untreated control cells.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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