FIGURE

Fig 5

ID

ZDB-FIG-211025-76

Publication

Sullivan et al., 2021 - Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

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Fig 5

A ATCC 19977, D436H mutant, and D436H:leuS^D complement strains were grown in Sauton media with 59 ?g/mL norvaline (top left), 66 ?g/mL leucine (top right), 59 ?g/mL valine (lower left), or 66 ?g/mL isoleucine (lower right). Data shown is from three biological replicates, one-way ANOVA with Tukey?s multiple comparisons test. ****, p < 0.0001. B D436H mutant grown in Sauton media with 59 ?g/mL norvaline and a range of leucine (left), isoleucine (middle), or valine (right). D436H mutant grown in 0 ?g/mL norvaline and 0 ?g/mL BCAA represents growth control. D436H mutant grown in 59 ?g/mL norvaline and 0 ?g/mL BCAA represents inhibited growth control. BCAAs added to cultures from 33 ?g/mL to 262 ?g/mL (Leu/Ile) or 29 ?g/mL to 234 ?g/mL (Val). Data shown is mean � SD from three biological replicates. Groups compared to inhibited growth control with one-way ANOVA with Dunnett?s multiple comparisons test. ***, p = 0.0009; ****, p ? 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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