FIGURE
Fig 4
- ID
- ZDB-FIG-211025-75
- Publication
- Sullivan et al., 2021 - Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline
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Fig 4
EPT-AMP (blue) bound in the active site of M. abscessus LeuRS (cyan) and a similar benzoxaborole-AMP (brown) bound in active site of M. tuberculosis LeuRS (PDB 5AGR) (orange). A Critical arginine and aspartic acid residues make similar interactions with benzoxaboroles. B Phosphate from AMP pivots towards threonine residue in M. abscessus LeuRS. Conformer 1 of T323 points OH towards EPT, while conformer 2 orients OH towards the phosphate. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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