FIGURE

Figure 5

ID

ZDB-FIG-210915-92

Publication

Schellens et al., 2021 - Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa

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Figure 5

Immunohistochemistry on retinal sections of wild-type, eys^KO and eys^Δexon40-44 zebrafish. Retinal cryosections of wild-type, eys^KO and eys^Δexon40-44 larvae (5 days post fertilization (dpf)) stained with antibodies directed against Eys (red) and centrin (green). Nuclei are counterstained with DAPI (blue). In eys^KO and in eys^Δex40-44 zebrafish retinas no Eys signal was detected, whereas in the retinas of wild-type larvae Eys was present adjacent to the centrin immunoreactivity. Scale bar: 10 μm. OS: outer segment, CC: connecting cilium, IS: inner segment, ONL: outer nuclear layer.

Expression Data

Gene:	eys
Antibodies:	Ab1-cetn Ab1-eys
Fish:	TL eys^rmc9/rmc9 (TL) eys^{rmc101/rmc101} (TL)
Anatomical Term:	eye photoreceptor cell photoreceptor connecting cilium
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eys^rmc9/rmc9 (TL) eys^{rmc101/rmc101} (TL)
Observed In:	eye photoreceptor cell photoreceptor connecting cilium
Stage:	Day 5

Phenotype Detail

Acknowledgments

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