ZFIN is now using GRCz12tu for Genomic Data
Gene
eys
- ID
- ZDB-GENE-130530-959
- Name
- EGF-like photoreceptor maintenance factor
- Symbol
- eys Nomenclature History
- Previous Names
-
- si:ch211-69e5.1
- zmp:0000000956
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Notch binding activity. Acts upstream of or within several processes, including opsin transport; photoreceptor cell development; and photoreceptor cell maintenance. Is expressed in brain; eye; gonad; liver; and muscle. Used to study cone-rod dystrophy and retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa 25. Orthologous to human EYS (EGF-like photoreceptor maintenance factor).
- Genome Resources
- Note
-
eys is represented by two partial Ensembl gene models in GRCz11.
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 22 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 25 | Alliance | Retinitis pigmentosa 25 | 602772 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Laminin G domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AC58H2U6 | InterPro | 2904 | ||||||||
| UniProtKB:A0AC58H2V0 | InterPro | 1538 | ||||||||
| UniProtKB:A0AC58H2V3 | InterPro | 1538 | ||||||||
| UniProtKB:A0AC58H2V7 | InterPro | 2283 | ||||||||
| UniProtKB:A0AC58H2W7 | InterPro | 2904 | ||||||||
| UniProtKB:B8JI71 | InterPro | 2904 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-eys | polyclonal | IgG | Rabbit |
|
Novus Biologicals, LLC
|
9 |
Plasmids
No data available
- Genome Browsers