FIGURE

Figure 7

ID

ZDB-FIG-210915-94

Publication

Schellens et al., 2021 - Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa

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Figure 7

Visual Motor Responses in wild-type, eys^KO and eys^Δexon40-44 zebrafish. (A) A representative eye-specific Light-ON Visual Motor Response (VMR) from a single trial, presented as the distance moved (mm) per second, is shown for the time frame of 15 s prior to and after light alternation. Note that the response to light is less pronounced in the eys^KO and eys^Δexon40-44 larvae as compared to the strain- and age-matched wild-type larvae (5 dpf; n = 16 per group). (B) The distance moved (mm, mean of 4 Light-ON transitions per larva) during the first second after the Light-ON transition for wild-type, eys^KO and eys^Δexon40-44 zebrafish. The distance moved was significantly lower in the eys^Δexon40-44 larvae (2.04 mm ± 0.66 (mean ± SD, n = 48)) than in wild-type larvae (2.72 mm ± 0.93 (mean ± SD, n = 48)), while no significant difference was observed between the eys^KO larvae (1.75 mm ± 0.57 (mean ± SD, n = 47)) and eys^Δexon40-44 larvae (5 dpf; n= 47 larvae). *** indicates p < 0.0001. Trials were conducted as 3 biological replicates containing all genotypes in each trial.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eys^rmc9/rmc9 (TL) eys^{rmc101/rmc101} (TL)
Condition:	lighting conditions
Observed In:	visual behavior visual perception
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.