FIGURE

Figure 1

ID

ZDB-FIG-210822-8

Publication

Holmgren et al., 2021 - Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

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Figure 1

Mitochondrial homeostasis in WT and mpv17^a9/a9 neuromasts. (A,B) Maximum-intensity projections of confocal images showing CellROX Green staining in WT siblings (A) and mpv17^a9/a9(B) neuromasts. Neuromast boundaries were delineated based on DIC images (not shown). (C) Mean CellROX intensity is elevated in mpv17^a9/a9 neuromasts (****P < 0.0001). n = 21–23 neuromasts; N = 2 experimental trials. (D,E) Maximum-intensity projections of confocal images showing mitoGCaMP3 fluorescence in WT (D) and mpv17^a9/a9(E) neuromasts. (F) Mean mitoGCaMP3 intensity is increased in mpv17^a9/a9 neuromasts (****P < 0.0001). n = 30–35 neuromasts (L3, L4, and L5); N = 2 experimental trials. Scale bars: 5 μm. Error bars: SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.