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Figure 1

ID: ZDB-IMAGE-210822-10
Publication: Holmgren et al., 2021 - Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line
All Figures: Figures for Holmgren et al., 2021

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Figure 1

Mitochondrial homeostasis in WT and mpv17^a9/a9 neuromasts. (A,B) Maximum-intensity projections of confocal images showing CellROX Green staining in WT siblings (A) and mpv17^a9/a9(B) neuromasts. Neuromast boundaries were delineated based on DIC images (not shown). (C) Mean CellROX intensity is elevated in mpv17^a9/a9 neuromasts (****P < 0.0001). n = 21–23 neuromasts; N = 2 experimental trials. (D,E) Maximum-intensity projections of confocal images showing mitoGCaMP3 fluorescence in WT (D) and mpv17^a9/a9(E) neuromasts. (F) Mean mitoGCaMP3 intensity is increased in mpv17^a9/a9 neuromasts (****P < 0.0001). n = 30–35 neuromasts (L3, L4, and L5); N = 2 experimental trials. Scale bars: 5 μm. Error bars: SEM.

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