FIGURE

Figure 4

ID

ZDB-FIG-210822-11

Publication

Holmgren et al., 2021 - Influence of Mpv17 on Hair-Cell Mitochondrial Homeostasis, Synapse Integrity, and Vulnerability to Damage in the Zebrafish Lateral Line

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Figure 4

mpv17^a9/a9 larvae are more sensitive to neomycin-induced hair-cell loss. (A–D) Maximum-intensity projections of confocal images of WT (A,B) and mpv17^a9/a9(C,D) control neuromasts (A–C) or exposed to 10 μM neomycin (B,D). Hair cells were visualized with immunolabel of Parvalbumin (magenta), afferent neurites are expressing GFP (green), and all cell nuclei are labeled with DAPI (blue). (E) Dose-response curves showing hair cell survival as a percentage of control in both WT and mpv17^a9/a9 neuromasts (*P = 0.0115; ***P = 0.0001; ****P < 0.0001). n = 67–86 neuromasts (L3, L4, and L5); N = 3 experimental trials. Scale bar: 5 μm. Error bars: SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.